Protection Against Lethal Marburg Virus Infection Mediated by Lipid Encapsulated Small Interfering RNA

201355 citationsJournal Articlehybrid Open Access

Authors

Raùl Ursic-Bedoya · Arbutus Biopharma (Canada)

Chad E. Mire · Galveston College

Marjorie Robbins · Arbutus Biopharma (Canada)

Joan B. Geisbert · Galveston College

Adam D. Judge · Arbutus Biopharma (Canada)

Ian MacLachlan · Arbutus Biopharma (Canada)

Thomas W. Geisbert ·

Abstract

These data show protective efficacy against the most pathogenic Angola strain of MARV. Further development of the lipid nanoparticle technology has the potential to yield effective treatments for MARV infection.

Topics & Keywords

Viral Infections and Outbreaks Research Hepatitis B Virus Studies Viral Infections and Vectors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 209, Issue 4, pp. 562-570

DOI: 10.1093/infdis/jit465

Field-Weighted Citation Impact: 3.98