Reduction in Neural-Tube Defects after Folic Acid Fortification in Canada

2007844 citationsJournal Article

Authors

Philippe De Wals · Université Laval

Fassiatou Tairou · Université Laval

Margot I. Van Allen · University of British Columbia

Soo-Hong Uh · Ministry of Health

R. Brian Lowry · Alberta Health

Barbara Sibbald · Alberta Health

Jane Evans ·

Abstract

Food fortification with folic acid was associated with a significant reduction in the rate of neural-tube defects in Canada. The decrease was greatest in areas in which the baseline rate was high.

Topics & Keywords

Folate and B Vitamins Research Congenital Anomalies and Fetal Surgery Pregnancy and preeclampsia studies

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: New England Journal of Medicine

Volume 357, Issue 2, pp. 135-142

DOI: 10.1056/nejmoa067103

Field-Weighted Citation Impact: 35.87