SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease

2013365 citationsJournal Articlebronze Open Access

Authors

Gabriele Calaminus · Addenbrooke's Hospital

Rolf‐Dieter Kortmann · Centre Léon Bérard

Jennifer Worch · Royal Marsden Hospital

James C. Nicholson · Institut Gustave Roussy

Claire Alapetite · Institut d’Hématologie et d’Oncologie Pédiatrique

Maria Luisa Garrè · Royal Marsden Hospital

Catherine Patte

Abstract

Localized germinoma can be treated with reduced dose CSI alone or with chemotherapy and reduced-field radiotherapy. The pattern of relapse suggests inclusion of ventricles in the radiation field. Reduced-dose craniospinal radiation alone is effective in metastatic disease.

Topics & Keywords

Glioma Diagnosis and Treatment Brain Metastases and Treatment Neuroblastoma Research and Treatments

Publication Details

Published in: Neuro-Oncology

Volume 15, Issue 6, pp. 788-796

DOI: 10.1093/neuonc/not019

Field-Weighted Citation Impact: 9.45

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SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease

Authors

Abstract

Topics & Keywords

Publication Details