A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients With Previously Untreated Metastatic Colorectal Cancer

20032,265 citationsJournal Article

Authors

Richard M. Goldberg · North Central Cancer Treatment Group

Daniel J. Sargent · North Central Cancer Treatment Group

Roscoe F. Morton · North Central Cancer Treatment Group

Charles S. Fuchs · North Central Cancer Treatment Group

Ramesh K. Ramanathan · North Central Cancer Treatment Group

Stephen K. Williamson · North Central Cancer Treatment Group

B. Findlay

Abstract

The FOLFOX regimen of oxaliplatin and infused fluorouracil plus leucovorin was active and comparatively safe. It should be considered as a standard therapy for patients with advanced colorectal cancer.

Topics & Keywords

Colorectal Cancer Treatments and Studies Cancer Treatment and Pharmacology Gastric Cancer Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 22, Issue 1, pp. 23-30

DOI: 10.1200/jco.2004.09.046

Field-Weighted Citation Impact: 66.41