Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

2009409 citationsJournal Article

Authors

Paméla Gasse · Université d'Orléans

Nicolas Riteau · Université d'Orléans

Sabine Charron · Université d'Orléans

Sandra Girre · Université d'Orléans

Lizette Fick · Institute of Immunology

Virginie Pétrilli · University of Lausanne

Jürg Tschopp ·

Abstract

Uric acid released from injured cells constitutes a major endogenous danger signal that activates the NALP3 inflammasome, leading to IL-1beta production. Reducing uric acid tissue levels represents a novel therapeutic approach to control IL-1beta production and chronic inflammatory lung pathology.

Topics & Keywords

Inflammasome and immune disorders Heme Oxygenase-1 and Carbon Monoxide Gout, Hyperuricemia, Uric Acid

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 179, Issue 10, pp. 903-913

DOI: 10.1164/rccm.200808-1274oc

Field-Weighted Citation Impact: 13.98