Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Authors

Thorlákur Jónsson · deCODE Genetics (Iceland)

Hreinn Stefánsson · deCODE Genetics (Iceland)

Stacy Steinberg · deCODE Genetics (Iceland)

Ingileif Jónsdóttir · University of Iceland

Pálmi V. Jónsson · National University Hospital of Iceland

Jón Snædal · National University Hospital of Iceland

Sigurbjörn Björnsson

Abstract

Our findings strongly implicate variant TREM2 in the pathogenesis of Alzheimer's disease. Given the reported antiinflammatory role of TREM2 in the brain, the R47H substitution may lead to an increased predisposition to Alzheimer's disease through impaired containment of inflammatory processes. (Funded by the National Institute on Aging and others.).

Topics & Keywords

Alzheimer's disease research and treatments Diabetes, Cardiovascular Risks, and Lipoproteins Lipoproteins and Cardiovascular Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 368, Issue 2, pp. 107-116

DOI: 10.1056/nejmoa1211103

Field-Weighted Citation Impact: 76.06