Comparison of the Effects of Bupivacaine and Ropivacaine on Heart Cell Mitochondrial Bioenergetics

1998199 citationsJournal Articlebronze Open Access

Authors

Jean-Pierre Mazat · Scientific Research Institute of Biochemistry

Abstract

Ropivacaine disturbs mitochondrial energy metabolism less than bupivacaine does. The lower lipid solubility of ropivacaine may be responsible for the lesser dose-dependent effects of this drug on mitochondrial bioenergetics.

Topics & Keywords

Cardiac Ischemia and Reperfusion Anesthesia and Neurotoxicity Research Nitric Oxide and Endothelin Effects

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Anesthesiology

Volume 88, Issue 5, pp. 1340-1349

DOI: 10.1097/00000542-199805000-00026

Field-Weighted Citation Impact: 4.89