CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

2014267 citationsJournal Article

Authors

Josef Ehling · RWTH Aachen University

Matthias Bartneck · RWTH Aachen University

Xiao Wei · RWTH Aachen University

Felix Gremse · RWTH Aachen University

Viktor Fech · RWTH Aachen University

Diana Möckel · RWTH Aachen University

Christer Baeck ·

Abstract

Inflammation-associated angiogenesis is promoted by CCL2-dependent monocytes during fibrosis progression. Innovative in vivo µCT methodology can accurately monitor angiogenesis and antiangiogenic therapy effects in experimental liver fibrosis.

Topics & Keywords

Liver physiology and pathology Hepatocellular Carcinoma Treatment and Prognosis Cancer Mechanisms and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 63, Issue 12, pp. 1960-1971

DOI: 10.1136/gutjnl-2013-306294

Field-Weighted Citation Impact: 13.27