Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice

2005430 citationsJournal Articlebronze Open Access

Authors

Anna Dikalova · Monash University

Roza E. Clempus · Monash University

Bernard Lassègue · Monash University

Guangjie Cheng · Monash University

James McCoy · Monash University

Sergey Dikalov · Monash University

Alejandra San Martín · Monash University

Abstract

These data indicate that smooth muscle-specific Nox1 overexpression augments the oxidative, pressor, and hypertrophic responses to Ang II, supporting the concept that medial Nox1 participates in the development of cardiovascular pathologies.

Topics & Keywords

Nitric Oxide and Endothelin Effects Eicosanoids and Hypertension Pharmacology Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Publication Details

Published in: Circulation

Volume 112, Issue 17, pp. 2668-2676

DOI: 10.1161/circulationaha.105.538934

Field-Weighted Citation Impact: 13.64

Command Palette

Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice

Authors

Abstract

Topics & Keywords

Publication Details