Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women

20031,852 citationsJournal Article

Authors

Rowan T. Chlebowski · University of California, Los Angeles

Susan L. Hendrix · Wayne State University

Robert D. Langer · University of California, San Diego

Marcia L. Stefanick · Stanford University

Margery Gass · University of Cincinnati

Dorothy S. Lane · Stony Brook University

Rebecca J. Rodabough

Abstract

Relatively short-term combined estrogen plus progestin use increases incident breast cancers, which are diagnosed at a more advanced stage compared with placebo use, and also substantially increases the percentage of women with abnormal mammograms. These results suggest estrogen plus progestin may stimulate breast cancer growth and hinder breast cancer diagnosis.

Topics & Keywords

Cancer Risks and Factors Global Cancer Incidence and Screening Breast Cancer Treatment Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 289, Issue 24, pp. 3243-3243

DOI: 10.1001/jama.289.24.3243

Field-Weighted Citation Impact: 72.63