Two Randomized Trials of Linaclotide for Chronic Constipation

2011368 citationsJournal Articlebronze Open Access

Authors

Anthony Lembo · Harvard University

Harvey Schneier

Steven J. Shiff

Caroline B. Kurtz · Ironwood Pharmaceuticals (United States)

James E. MacDougall · Ironwood Pharmaceuticals (United States)

Xinwei D. Jia

James Shao · Ironwood Pharmaceuticals (United States)

Bernard J. Lavins · Ironwood Pharmaceuticals (United States)

Abstract

In these two 12-week trials, linaclotide significantly reduced bowel and abdominal symptoms in patients with chronic constipation. Additional studies are needed to evaluate the potential long-term risks and benefits of linaclotide in chronic constipation. (Funded by Ironwood Pharmaceuticals and Forest Research Institute; ClinicalTrials.gov numbers, NCT00765882 and NCT00730015.).

Topics & Keywords

Gastrointestinal motility and disorders Congenital gastrointestinal and neural anomalies Gastroesophageal reflux and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 365, Issue 6, pp. 527-536

DOI: 10.1056/nejmoa1010863

Field-Weighted Citation Impact: 20.99