HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

2015153 citationsJournal Articlegold Open Access

Authors

Andrew E. Teschendorff · Genomics England

Shih-Han Lee · University College London

Allison Jones · University College London

Heidi Fiegl · Innsbruck Medical University

Marie Kalwa · RWTH Aachen University

Wolfgang Wagner · RWTH Aachen University

Kantaraja Chindera ·

Abstract

Non-coding RNA HOTAIR or its more stable DNAme surrogate may indicate the presence of a subset of cells which confer resistance to carboplatin and can serve as (1) a marker to personalise treatment and (2) a novel target to overcome carboplatin resistance.

Topics & Keywords

UN Sustainable Development Goals

No povertyGood health and well-being

Publication Details

Published in: Genome Medicine

Volume 7, Issue 1, pp. 108-108

DOI: 10.1186/s13073-015-0233-4

Field-Weighted Citation Impact: 6.68