Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair

2014217 citationsJournal Articlebronze Open Access

Authors

Milena B. Furtado · Baker Heart and Diabetes Institute

Mauro W. Costa · Baker Heart and Diabetes Institute

Edward A. Pranoto · Indiana University School of Medicine

Ekaterina Salimova · Indiana University School of Medicine

Alexander R. Pinto · Indiana University – Purdue University Indianapolis

Nicholas T. Lam · Indiana University School of Medicine

Anthony Park

Abstract

The surprising transcriptional identity of cardiac fibroblasts, the adoption of cardiogenic gene programs, and direct contribution to cardiac development and repair provoke alternative interpretations for studies on more specialized cardiac progenitors, offering a novel perspective for reinterpreting cardiac regenerative therapies.

Topics & Keywords

Congenital heart defects research Tissue Engineering and Regenerative Medicine Cardiac Fibrosis and Remodeling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 114, Issue 9, pp. 1422-1434

DOI: 10.1161/circresaha.114.302530

Field-Weighted Citation Impact: 10.27