Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia

2007220 citationsJournal Articlegold Open Access

Authors

Eduardo Candelario‐Jalil · University of Freiburg

Antônio Carlos Pinheiro de Oliveira · University of Freiburg

Sybille Gräf · University of Freiburg

Harsharan S. Bhatia · University of Freiburg

Michael Hüll · University Medical Center Freiburg

Eduardo Muñóz · University of Córdoba

Bernd L. Fiebich

Abstract

These findings suggest that the naturally occurring polyphenol resveratrol is able to reduce microglial activation, an effect that might help to explain its neuroprotective effects in several in vivo models of brain injury.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Sirtuins and Resveratrol in Medicine Medicinal Plants and Neuroprotection

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 4, Issue 1, pp. 25-25

DOI: 10.1186/1742-2094-4-25

Field-Weighted Citation Impact: 10.01