Frontal-Striatal Dysfunction During Planning in Obsessive-Compulsive Disorder

2005415 citationsJournal Articlegreen Open Access

Authors

Odile A. van den Heuvel

Dick J. Veltman

Henk J. Groenewegen · Center for Neurosciences

Daniëlle C. Cath

Anton J.L.M. van Balkom

Julie van Hartskamp · Vrije Universiteit Amsterdam

Frederik Barkhof

Richard van Dyck

Abstract

These findings support the hypothesis that decreased dorsal prefrontal-striatal responsiveness is associated with impaired planning capacity in OCD patients. Because the described frontal-striatal dysfunction in OCD is independent of state anxiety and disease symptom severity, we conclude that executive impairment is a core feature in OCD.

Topics & Keywords

Obsessive-Compulsive Spectrum Disorders Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neural and Behavioral Psychology Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of General Psychiatry

Volume 62, Issue 3, pp. 301-301

DOI: 10.1001/archpsyc.62.3.301

Field-Weighted Citation Impact: 20.45