5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

2008764 citationsReviewgold Open Access

Authors

Ning Zhang · Zhejiang University

Ying Yin · Zhejiang University

Shengjie Xu · Sir Run Run Shaw Hospital

Weishan Chen · Zhejiang University

Abstract

The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.

Topics & Keywords

Colorectal Cancer Treatments and Studies Gastric Cancer Management and Outcomes Cancer Research and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecules

Volume 13, Issue 8, pp. 1551-1569

DOI: 10.3390/molecules13081551

Field-Weighted Citation Impact: 3.11