Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies

2012765 citationsJournal Articlebronze Open Access

Authors

Andrew E. Jaffe · Johns Hopkins University

Peter Murakami · Johns Hopkins University

Hwa-Jin Lee · Johns Hopkins University

Jeffrey T. Leek · Johns Hopkins University

M. Daniele Fallin · Johns Hopkins University

Andrew P. Feinberg · Johns Hopkins University

Rafael A. Irizarry ·

Abstract

Our framework offers a comprehensive yet flexible approach for identifying genomic regions of biological interest in large epidemiological studies using quantitative high-throughput methods.

Topics & Keywords

Epigenetics and DNA Methylation Genetic Syndromes and Imprinting Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Journal of Epidemiology

Volume 41, Issue 1, pp. 200-209

DOI: 10.1093/ije/dyr238

Field-Weighted Citation Impact: 16.41