A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

2010741 citationsJournal Article

Authors

Roberta Magliozzi · Imperial College London

Owain W. Howell · Imperial College London

Cheryl Reeves · Imperial College London

Federico Roncaroli · Imperial College London

Richard Nicholas · Imperial College London

Barbara Serafini · Istituto Superiore di Sanità

Francesca Aloisi ·

Abstract

We demonstrate substantial cortical neurodegeneration and generalized cell loss in progressive MS in association with meningeal inflammation and lymphoid tissue formation, supporting the hypothesis that cytotoxic factors diffusing from the meningeal compartment contribute to grey matter pathology and the consequent increase in clinical disability.

Topics & Keywords

Multiple Sclerosis Research Studies Peripheral Neuropathies and Disorders Neurogenesis and neuroplasticity mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 68, Issue 4, pp. 477-493

DOI: 10.1002/ana.22230

Field-Weighted Citation Impact: 16.45