Clinical relevance and functional consequences of the <i>TNFRSF1A</i> multiple sclerosis locus

201337 citationsJournal Articlebronze Open Access

Authors

Linda Ottoboni · Massachusetts Institute of Technology

Irene Y. Frohlich · Harvard University

Michelle Lee · Harvard University

Brian C. Healy · Harvard University

Brendan T Keenan · Harvard University

Zongqi Xia · Broad Institute

Tanuja Chitnis ·

Abstract

The MS rs1800693(G) susceptibility allele affects the magnitude of monocyte responses to TNF-α stimulation, and the TNF pathway may be one network in which the effect of multiple MS genes becomes integrated.

Topics & Keywords

Multiple Sclerosis Research Studies Immune Response and Inflammation RNA regulation and disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 81, Issue 22, pp. 1891-1899

DOI: 10.1212/01.wnl.0000436612.66328.8a

Field-Weighted Citation Impact: 2.77