Apoptosis in myocardial ischaemia and infarction

2002330 citationsReviewbronze Open Access

Authors

Paul A.J. Krijnen · Amsterdam UMC Location VUmc

R Nijmeijer · Amsterdam UMC Location VUmc

C J L M Meijer · Amsterdam UMC Location VUmc

C A Visser · Amsterdam UMC Location VUmc

C E Hack · University Clinical Centre

H W M Niessen · Amsterdam UMC Location VUmc

Abstract

Recent studies indicate that, in addition to necrosis, apoptosis also plays a role in the process of tissue damage after myocardial infarction, which has pathological and therapeutic implications. This review article will discuss studies in which the role and mechanisms of apoptosis in myocardial infarction were analysed in vivo and in vitro in humans and in animals.

Topics & Keywords

Cell death mechanisms and regulation Cardiac Ischemia and Reperfusion Calpain Protease Function and Regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Pathology

Volume 55, Issue 11, pp. 801-811

DOI: 10.1136/jcp.55.11.801

Field-Weighted Citation Impact: 3.08