Del(6)(q22) and <i>BCL6</i> Rearrangements in Primary CNS Lymphoma Are Indicators of an Aggressive Clinical Course

Del (6)(q22) and BCL6 rearrangements are common in PCNSL and predict for decreased OS independent of deep structure involvement and HDMTX. Unlike systemic diffuse large B-cell lymphoma, del(6)(q22) is common and IGH translocations are infrequent and usually involve BCL6 rather than BCL2, suggesting a distinct pathogenesis.