Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling

2006309 citationsJournal Articlebronze Open Access

Authors

Ni Yan · Research Institute of Radiology

Kambeez Berenji · Research Institute of Radiology

Na Wang · Research Institute of Radiology

Misook Oh · Research Institute of Radiology

Nita Sachan · Research Institute of Radiology

Asim Dey · Research Institute of Radiology

Jun Cheng

Abstract

This study suggests that inhibition of the calcineurin/NFAT signaling cascade by Foxo and release of this repressive action by the PI3K/Akt pathway are important mechanisms whereby Foxo factors govern cell growth in the heart.

Topics & Keywords

Signaling Pathways in Disease FOXO transcription factor regulation Heat shock proteins research

Publication Details

Published in: Circulation

Volume 114, Issue 11, pp. 1159-1168

DOI: 10.1161/circulationaha.106.637124

Field-Weighted Citation Impact: 6.54

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Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling

Authors

Abstract

Topics & Keywords

Publication Details