Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis

20121,824 citationsJournal Article

Authors

Anders Perner · Rigshospitalet

Nicolai Haase

Anne Berit Guttormsen · University of Bergen

Jyrki Tenhunen · Uppsala University

Gudmundur Klemenzson · National University Hospital of Iceland

Anders Åneman · South Western Sydney Local Health District

Kristian Rørbæk Madsen

Morten Hylander Møller

Abstract

Patients with severe sepsis assigned to fluid resuscitation with HES 130/0.42 had an increased risk of death at day 90 and were more likely to require renal-replacement therapy, as compared with those receiving Ringer's acetate. (Funded by the Danish Research Council and others; 6S ClinicalTrials.gov number, NCT00962156.).

Topics & Keywords

Sepsis Diagnosis and Treatment Hyperglycemia and glycemic control in critically ill and hospitalized patients Renal function and acid-base balance

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 367, Issue 2, pp. 124-134

DOI: 10.1056/nejmoa1204242

Field-Weighted Citation Impact: 143.13