Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury

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Authors

Konrad Teodor Sawicki · Northwestern University

Meng Shang · Northwestern University

Rongxue Wu · Northwestern University

Hsiang‐Chun Chang · Northwestern University

Arineh Khechaduri · Northwestern University

Tatsuya Sato · Northwestern University

Christine Kamide ·

Abstract

Heme accumulation is detrimental to cardiac function under ischemic conditions, and reducing heme in the heart may be a novel approach for protection against the development of heart failure.

Topics & Keywords

Heme Oxygenase-1 and Carbon Monoxide Hemoglobin structure and function Vitamin C and Antioxidants Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American Heart Association

Volume 4, Issue 8, pp. e002272-e002272

DOI: 10.1161/jaha.115.002272

Field-Weighted Citation Impact: 1.96