High Prevalence of Respiratory Ciliary Dysfunction in Congenital Heart Disease Patients With Heterotaxy

2012189 citationsJournal Articlebronze Open Access

Authors

Nader Nakhleh · University of North Carolina at Chapel Hill

Richard Francis · Children's National

Rachel Giese · University of North Carolina at Chapel Hill

Xin Tian · University of North Carolina at Chapel Hill

You Li · National Institute of Allergy and Infectious Diseases

Maimoona A. Zariwala · National Institute of Allergy and Infectious Diseases

Hisato Yagi

Abstract

Our studies show that CHD patients with heterotaxy have substantial risk for CD and increased respiratory disease. Heterotaxy patients with CD were enriched for mutations in PCD genes. Future studies are needed to assess the potential benefit of prescreening and prophylactically treating heterotaxy patients for CD.

Topics & Keywords

Tracheal and airway disorders Genetic and Kidney Cyst Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 125, Issue 18, pp. 2232-2242

DOI: 10.1161/circulationaha.111.079780

Field-Weighted Citation Impact: 13.91