Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats

201193 citationsJournal Articlehybrid Open Access

Authors

Allen C. Clermont · Joslin Diabetes Center

Tamie J. Chilcote · ActiveSite Pharmaceuticals (United States)

Takeshi Kita · Joslin Diabetes Center

Jia Liu · Joslin Diabetes Center

Priscilla Riva · Joslin Diabetes Center

Sukanto Sinha · ActiveSite Pharmaceuticals (United States)

Edward P. Feener

Abstract

These results show that PK contributes to retinal vascular dysfunctions in diabetic rats and that the combination of diabetes and intravitreal injection of PK in rats induces retinal thickening.

Topics & Keywords

Coagulation, Bradykinin, Polyphosphates, and Angioedema Blood Coagulation and Thrombosis Mechanisms Retinal Diseases and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 60, Issue 5, pp. 1590-1598

DOI: 10.2337/db10-1260

Field-Weighted Citation Impact: 3.81