A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling

20061,008 citationsJournal Articlebronze Open Access

Authors

Michael Hummel · Charité - Universitätsmedizin Berlin

Stefan Bentink

Abstract

Our molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt's lymphoma. In mature aggressive B-cell lymphomas without a gene signature for Burkitt's lymphoma, chromosomal breakpoints at the myc locus were associated with an adverse clinical outcome.

Topics & Keywords

Lymphoma Diagnosis and Treatment Cancer Genomics and Diagnostics Chronic Lymphocytic Leukemia Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 354, Issue 23, pp. 2419-2430

DOI: 10.1056/nejmoa055351

Field-Weighted Citation Impact: 40.82