Risk-Reducing Salpingo-Oophorectomy in <i>BRCA</i> Mutation Carriers: Role of Serial Sectioning in the Detection of Occult Malignancy

A rigorous operative and pathologic protocol for RRSO increases the detection rate of occult ovarian malignancy in BRCA mutation carriers nearly seven-fold. If confirmed, this finding will alter postoperative management because additional staging, chemotherapy, and follow-up may be necessary in affected women.