Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques

201254 citationsJournal Articlebronze Open Access

Authors

Karl Malcolm · Queen's University Belfast

Claire Forbes · Queen's University Belfast

Laura A. Geer · Lubrizol Life Science Health (United States)

Ronald S. Veazey · Tulane University

Lynn R. Goldman · Lubrizol Life Science Health (United States)

P. J. Klasse · Cornell University

J. P. Moore

Abstract

A high degree of correlation between PK and efficacy was observed. Based on the data obtained with the 3.3% w/w maraviroc gel, maintenance of vaginal fluid and tissue levels in the order of 10(7) ng/mL and 10(3) ng/g, respectively, are required for complete protection with this compound.

Topics & Keywords

HIV Research and Treatment Mosquito-borne diseases and control HIV/AIDS Research and Interventions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 68, Issue 3, pp. 678-683

DOI: 10.1093/jac/dks422

Field-Weighted Citation Impact: 4.40