Pharmacogenetics of plasma efavirenz exposure in HIV‐infected adults and children in South Africa

201582 citationsJournal Articlebronze Open Access

Authors

Phumla Sinxadi · University of Cape Town

Paul Leger · Vanderbilt University Medical Center

Helen McIlleron · University of Cape Town

Peter J. Smith · University of Cape Town

Joel A. Dave · University of Cape Town

Naomi Levitt · University of Cape Town

Gary Maartens ·

Abstract

Composite CYP2B6 genotype based on CYP2B6 516G→T, 983T→C, and 15582C→T best described efavirenz exposure in HIV-infected Black South African adults and children.

Topics & Keywords

HIV/AIDS drug development and treatment Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Clinical Pharmacology

Volume 80, Issue 1, pp. 146-156

DOI: 10.1111/bcp.12590

Field-Weighted Citation Impact: 5.63