Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study

2013502 citationsJournal Articlegold Open Access

Authors

Andreas Roetzer · Research Center Borstel - Leibniz Lung Center

Roland Diel · University Hospital Schleswig-Holstein

Thomas A. Kohl · Research Center Borstel - Leibniz Lung Center

Christian Rückert · Bielefeld University

Ulrich Nübel · Robert Koch Institute

Jochen Blom · Bielefeld University

Thierry Wirth

Abstract

Our findings suggest that WGS is superior to conventional genotyping for Mtb pathogen tracing and investigating micro-epidemics. WGS provides a measure of Mtb genome evolution over time in its natural host context.

Topics & Keywords

Tuberculosis Research and Epidemiology Mycobacterium research and diagnosis Infectious Diseases and Tuberculosis

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: PLoS Medicine

Volume 10, Issue 2, pp. e1001387-e1001387

DOI: 10.1371/journal.pmed.1001387

Field-Weighted Citation Impact: 31.06