Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy

2010456 citationsJournal Articlebronze Open Access

Authors

Robert M. Prins · University of California, Los Angeles

Horacio Soto · University of California, Los Angeles

Vera Konkankit · University of California, Los Angeles

Sylvia K. Odesa · University of California, Los Angeles

Ascia Eskin · University of California, Los Angeles

William H. Yong · University of California, Los Angeles

Stanley F. Nelson

Abstract

Autologous tumor lysate-pulsed DC vaccination in conjunction with TLR agonists is safe as adjuvant therapy in newly diagnosed and recurrent glioblastoma patients. Our results suggest that the mesenchymal gene expression profile may identify an immunogenic subgroup of glioblastoma that may be more responsive to immune-based therapies.

Topics & Keywords

Immunotherapy and Immune Responses Glioma Diagnosis and Treatment Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 17, Issue 6, pp. 1603-1615

DOI: 10.1158/1078-0432.ccr-10-2563

Field-Weighted Citation Impact: 10.80