Unusual Roentgenographic Presentations of Multiple Myeloma

Three unusual roentgenographic manifestations of multiple myeloma have been presented: diffuse sclerosis, coexistent myeloma, amyloidosis, and solitary destructive myeloma involving almost an entire long bone. These appearances usually present diagnostic problems and a definite diagnosis is seldom made without biopsy or pertinent laboratory data. It is to be emphasized, nevertheless, that these manifestations are being recognized more and more frequently. Multiple myeloma should, therefore, be included when one considers the differential diagnosis of atypical skeletal roentgenograms.