Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis

2008513 citationsJournal Articlebronze Open Access

Authors

Peter A. Vadas

Milton Gold · Hospital for Sick Children

Boris Perelman · St Michael's Hospital

Gary M. Liss · Toronto Public Health

Gideon Lack · ENT and Allergy

T Blyth · St Mary's Hospital

F. Estelle R. Simons

Kai Simons · University of Manitoba

Abstract

Serum PAF levels were directly correlated and serum PAF acetylhydrolase activity was inversely correlated with the severity of anaphylaxis. PAF acetylhydrolase activity was significantly lower in patients with fatal anaphylactic reactions to peanuts than in patients in any of the control groups. Failure of PAF acetylhydrolase to inactivate PAF may contribute to the severity of anaphylaxis.

Topics & Keywords

Food Allergy and Anaphylaxis Research Platelet Disorders and Treatments Eosinophilic Esophagitis

Publication Details

Published in: New England Journal of Medicine

Volume 358, Issue 1, pp. 28-35

DOI: 10.1056/nejmoa070030

Field-Weighted Citation Impact: 16.86

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Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis

Authors

Abstract

Topics & Keywords

Publication Details