The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

2009181 citationsJournal Articlehybrid Open Access

Authors

Yaël Mamane · Merck Canada Inc. (Canada)

Chi Chung Chan · Merck Canada Inc. (Canada)

Geneviève Lavallée · Merck Canada Inc. (Canada)

Nicolas Morin · Merck Canada Inc. (Canada)

Lijing Xu · Merck Canada Inc. (Canada)

Jingqi Huang · Merck Canada Inc. (Canada)

Robert J. Gordon ·

Abstract

Overall, our results suggest that the C3aR in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Immune cells in cancer Regulation of Appetite and Obesity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 58, Issue 9, pp. 2006-2017

DOI: 10.2337/db09-0323

Field-Weighted Citation Impact: 6.30