EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

2015138 citationsJournal Articlegreen Open Access

Authors

Philip D. Dunne · Queen's University Belfast

Sonali Dasgupta · Queen's University Belfast

Jaine K. Blayney · Queen's University Belfast

Darragh G. McArt · Queen's University Belfast

Keara L. Redmond · Queen's University Belfast

Jessica-Anne Weir · Queen's University Belfast

Conor A. Bradley

Abstract

These data show that EpHA2 is a poor prognostic marker in stage II/III colorectal cancer, which may be due to its ability to promote cell migration and invasion, providing support for the further investigation of EphA2 as a novel prognostic biomarker and therapeutic target.

Topics & Keywords

Axon Guidance and Neuronal Signaling Angiogenesis and VEGF in Cancer Hippo pathway signaling and YAP/TAZ

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Clinical Cancer Research

Volume 22, Issue 1, pp. 230-242

DOI: 10.1158/1078-0432.ccr-15-0603

Field-Weighted Citation Impact: 6.01