Buprenorphine Metabolites, Buprenorphine-3-glucuronide and Norbuprenorphine-3-glucuronide, Are Biologically Active

2011163 citationsJournal Articlebronze Open Access

Authors

Sarah M. Brown · Washington University in St. Louis

Thomas Kim · Washington University in St. Louis

Abstract

Both glucuronide metabolites of buprenorphine are biologically active at doses relevant to metabolite exposures, which occur after buprenorphine. Activity of the glucuronides may contribute to the overall pharmacology of buprenorphine.

Topics & Keywords

Pain Mechanisms and Treatments Neuropeptides and Animal Physiology Opioid Use Disorder Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesiology

Volume 115, Issue 6, pp. 1251-1260

DOI: 10.1097/aln.0b013e318238fea0

Field-Weighted Citation Impact: 4.83