<i>ASS1</i> as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance

2013158 citationsJournal Article

Authors

Hsuan-Ying Huang · Chang Gung University

Wen-Ren Wu · National Health Research Institutes

Yu-Hui Wang · Chang Gung University

Junwen Wang · National Health Research Institutes

Fu-Min Fang · E-Da Hospital

Jen-Wei Tsai · E-Da Hospital

Shau-Hsuan Li ·

Abstract

Our findings highlight ASS1 as a novel tumor suppressor in myxofibrosarcomas, with loss of expression linked to promoter methylation, clinical aggressiveness, and sensitivity to ADI-PEG20.

Topics & Keywords

Cancer Research and Treatments Sarcoma Diagnosis and Treatment Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 19, Issue 11, pp. 2861-2872

DOI: 10.1158/1078-0432.ccr-12-2641

Field-Weighted Citation Impact: 13.15