Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

2012295 citationsJournal Article

Authors

Menghua Xiong · University of Science and Technology of China

Yajuan Li · Hefei National Center for Physical Sciences at Nanoscale

Yan Bao · Hefei National Center for Physical Sciences at Nanoscale

Xianzhu Yang · Hefei National Center for Physical Sciences at Nanoscale

Bing Hu · Hefei National Center for Physical Sciences at Nanoscale

Jun Wang · University of Science and Technology of China

Abstract

Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.

Topics & Keywords

Graphene and Nanomaterials Applications Nanoparticle-Based Drug Delivery Cancer Research and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Advanced Materials

Volume 24, Issue 46, pp. 6175-6180

DOI: 10.1002/adma.201202847

Field-Weighted Citation Impact: 7.24