Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort

2015151 citationsJournal Articlebronze Open Access

Authors

Jason I. Feinberg · Johns Hopkins University

Kelly M. Bakulski · Johns Hopkins University

Andrew E. Jaffe · Johns Hopkins University

Rakel Tryggvadóttir · Johns Hopkins University

Shannon Brown · Johns Hopkins University

Lynn R. Goldman · Johns Hopkins University

Lisa Croen ·

Abstract

These data suggest that epigenetic differences in paternal sperm may contribute to autism risk in offspring, and provide evidence that directionally consistent, potentially related epigenetic mechanisms may be operating in the cerebellum of individuals with autism.

Topics & Keywords

Autism Spectrum Disorder Research Epigenetics and DNA Methylation Child Development and Digital Technology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Journal of Epidemiology

Volume 44, Issue 4, pp. 1199-1210

DOI: 10.1093/ije/dyv028

Field-Weighted Citation Impact: 8.25