Predominant Hematopoietic Origin of Cell-free DNA in Plasma and Serum after Sex-mismatched Bone Marrow Transplantation

2002589 citationsJournal Articlebronze Open Access

Authors

Yanni YN Lui · Chinese University of Hong Kong

Ki-Wai Chik · Chinese University of Hong Kong

Rossa W. K. Chiu · Chinese University of Hong Kong

Cheong-Yip Ho · Prince of Wales Hospital

Christopher WK Lam · Prince of Wales Hospital

YM Dennis Lo · Chinese University of Hong Kong

Abstract

After bone marrow transplantation, the DNA in plasma and serum is predominantly hematopoietic in origin. Apart from the biological implications of this observation, this finding suggests that plasma and serum can be used as alternative materials for the study of postbone marrow transplantation chimerism.

Topics & Keywords

Prenatal Screening and Diagnostics Cancer Genomics and Diagnostics Renal and related cancers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 48, Issue 3, pp. 421-427

DOI: 10.1093/clinchem/48.3.421

Field-Weighted Citation Impact: 16.08