Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration

2012113 citationsJournal Articlegold Open Access

Authors

Changhua Zhou · Xavier University of Louisiana

Qiu Zhong · Xavier University of Louisiana

Lyndsay V. Rhodes · Tulane University

Ian K. Townley · Xavier University of Louisiana

Melyssa R. Bratton · Tulane University

Qiang Zhang · Xavier University of Louisiana

Elizabeth C. Martin ·

Abstract

Our data demonstrate that the adaptive changes in the proteome of tamoxifen resistant breast cancer cells are characterized by down-regulated ER signaling, activation of alternative survival pathways, and enhanced cell motility through regulation of the actin cytoskeleton dynamics. Evidence also emerged that S100P mediates acquired tamoxifen resistance and migration capacity.

Topics & Keywords

Clusterin in disease pathology Cancer, Hypoxia, and Metabolism Cytokine Signaling Pathways and Interactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Breast Cancer Research

Volume 14, Issue 2, pp. R45-R45

DOI: 10.1186/bcr3144

Field-Weighted Citation Impact: 4.83