The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

2013151 citationsJournal Articlehybrid Open Access

Authors

Nicole Gossan · University of Manchester

Leo Zeef · University of Manchester

James Hensman · University of Sheffield

Alun T. L. Hughes · University of Manchester

John F. Bateman · Murdoch Children's Research Institute

Lynn Rowley · Murdoch Children's Research Institute

Christopher B. Little

Abstract

These results reveal an autonomous circadian clock in chondrocytes that can be implicated in key aspects of cartilage biology and pathology. Consequently, circadian disruption (e.g., during aging) may compromise tissue homeostasis and increase susceptibility to joint damage or disease.

Topics & Keywords

Circadian rhythm and melatonin Olfactory and Sensory Function Studies Neurobiology and Insect Physiology Research

Publication Details

Published in: Arthritis & Rheumatism

Volume 65, Issue 9, pp. 2334-2345

DOI: 10.1002/art.38035

Field-Weighted Citation Impact: 6.82

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The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

Authors

Abstract

Topics & Keywords

Publication Details