Validity of composite end points in clinical trials

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Authors

Víctor M. Montori · Mayo Clinic

Gaietà Permanyer-Miralda

Ignacio Ferreira‐González · Universitat Autònoma de Barcelona

Jason W. Busse · McMaster University

Valeria Pacheco‐Huergo · Institut Català de la Salut

Dianne Bryant · McMaster University

Jordi Alonso · Municipal Institute for Medical Research

Abstract

Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?

Topics & Keywords

Meta-analysis and systematic reviews Health Systems, Economic Evaluations, Quality of Life Blood Pressure and Hypertension Studies

Publication Details

Published in: BMJ

Volume 330, Issue 7491, pp. 594-596

DOI: 10.1136/bmj.330.7491.594

Field-Weighted Citation Impact: 32.27

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Validity of composite end points in clinical trials

Authors

Abstract

Topics & Keywords

Publication Details