A Model of Human Tumor Dormancy: An Angiogenic Switch From the Nonangiogenic Phenotype

2006413 citationsJournal Articlebronze Open Access

Authors

George N. Naumov · Boston Children's Hospital

Elise R. Bender · Boston Children's Hospital

David Zurakowski · Harvard University

Soo-Young Kang · University of Bergen

David A. Sampson · Grieg Seafood (Norway)

Evelyn Flynn · Grieg Seafood (Norway)

Randolph S. Watnick ·

Abstract

This model provides a conceptual framework and a reproducible in vivo system to study unresolved central questions in cancer biology regarding the initiation, reversibility, and molecular regulation of the timing of the angiogenic switch.

Topics & Keywords

Angiogenesis and VEGF in Cancer Cancer, Hypoxia, and Metabolism Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 98, Issue 5, pp. 316-325

DOI: 10.1093/jnci/djj068

Field-Weighted Citation Impact: 15.47