5α-Reductase Type 1 Modulates Insulin Sensitivity in Men

201485 citationsJournal Articlebronze Open Access

Authors

Rita Upreti · British Heart Foundation Centre for Cardiovascular Science

Katherine A. Hughes · British Heart Foundation

Dawn E. W. Livingstone · British Heart Foundation Centre for Cardiovascular Science

Calum Gray · The Queen's Medical Research Institute

Fiona C. Minns

David P. Macfarlane · British Heart Foundation Centre for Cardiovascular Science

Ian Marshall ·

Abstract

Dual inhibition of 5αRs, but not inhibition of 5αR2 alone, modulates insulin sensitivity in human peripheral tissues rather than liver. This may have important implications for patients prescribed dutasteride for prostatic disease.

Topics & Keywords

Hormonal and reproductive studies Urinary Bladder and Prostate Research Sexual Differentiation and Disorders

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 99, Issue 8, pp. E1397-E1406

DOI: 10.1210/jc.2014-1395

Field-Weighted Citation Impact: 7.72

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5α-Reductase Type 1 Modulates Insulin Sensitivity in Men

Authors

Abstract

Topics & Keywords

Publication Details