Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

2012483 citationsJournal Article

Authors

Xiucui Ma · John Cochran VA Medical Center

Haiyan Liu · John Cochran VA Medical Center

Sarah R. Foyil · John Cochran VA Medical Center

Rebecca J. Godar · John Cochran VA Medical Center

Carla J. Weinheimer · John Cochran VA Medical Center

Joseph A. Hill · John Cochran VA Medical Center

Abhinav Diwan

Abstract

Ischemia/reperfusion injury impairs autophagosome clearance mediated in part by reactive oxygen species-induced decline in lysosome-associated membrane protein-2 and upregulation of BECLIN-1, contributing to increased cardiomyocyte death.

Topics & Keywords

Autophagy in Disease and Therapy Calcium signaling and nucleotide metabolism Endoplasmic Reticulum Stress and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 125, Issue 25, pp. 3170-3181

DOI: 10.1161/circulationaha.111.041814

Field-Weighted Citation Impact: 19.74