First-Trimester Screening for Trisomies 21 and 18

2003567 citationsJournal Articlebronze Open Access

Authors

Ronald J. Wapner · Drexel University

Elizabeth Thom

Joe Leigh Simpson · Baylor College of Medicine

Eugene Pergament · Northwestern University

Richard K. Silver

Karen Filkins · Oklahoma State University Center for Health Sciences

Lawrence D. Platt · Cedars-Sinai Medical Center

Maurice Mahoney

Abstract

First-trimester screening for trisomies 21 and 18 on the basis of maternal age, maternal levels of free beta human chorionic gonadotropin and pregnancy-associated plasma protein A, and measurement of fetal nuchal translucency has good sensitivity at an acceptable false positive rate.

Topics & Keywords

Prenatal Screening and Diagnostics Parvovirus B19 Infection Studies Gestational Trophoblastic Disease Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 349, Issue 15, pp. 1405-1413

DOI: 10.1056/nejmoa025273

Field-Weighted Citation Impact: 60.46