Molecular Changes in Tamoxifen-Resistant Breast Cancer: Relationship Between Estrogen Receptor, HER-2, and p38 Mitogen-Activated Protein Kinase

2005488 citationsJournal Articlebronze Open Access

Authors

Maya Gutierrez · Baylor College of Medicine

Simone Detre · Breast Center

Stephen Johnston · Baylor College of Medicine

Syed K. Mohsin · Royal Marsden NHS Foundation Trust

Jiang Shou · Breast Center

D. Craig Allred · Breast Center

Rachel Schiff ·

Abstract

The molecular pathways driving tumor growth can change as the tumor progresses. Crosstalk between ER, HER-2, p38, and ERK may contribute to tamoxifen resistance and may provide molecular targets to overcome this resistance.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 23, Issue 11, pp. 2469-2476

DOI: 10.1200/jco.2005.01.172

Field-Weighted Citation Impact: 17.98