TI‐VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes

2011114 citationsJournal Articlegreen Open Access

Authors

Claudia Verderio · University of Milan

Cinzia Cagnoli · Fondazione Filarete

Matteo Bergami · Italian Institute of Technology

Maura Francolini · Fondazione Filarete

Ursula Schenk · University of Milan

Alessio Colombo · University of Milan

Loredana Riganti ·

Abstract

Given that sustained ATP release from glia upon injury greatly contributes to secondary brain damage and cathepsin B plays a critical role in glioma dissemination, TI-VAMP silencing can represent a novel strategy to control lysosome fusion in pathological conditions.

Topics & Keywords

Cellular transport and secretion Autophagy in Disease and Therapy RNA Interference and Gene Delivery

Publication Details

Published in: Biology of the Cell

Volume 104, Issue 4, pp. 213-228

DOI: 10.1111/boc.201100070

Field-Weighted Citation Impact: 2.87

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TI‐VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes

Authors

Abstract

Topics & Keywords

Publication Details